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با این حال، به دلیل ماهیت کارآزماییهای مداخلات روانیاجتماعی، کورسازی شرکتکنندگان و پرسنل، و ارزیابی پیامد، تمایل زیادی به خطر سوگیری وجود داشت. به طور کلی، خطر سوگیری در مطالعات گنجانده شده در اکثر دامنهها در سطح پائین یا نامشخصی قرار داشت. دو نویسنده مستقلا، خطر سوگیری (bias) مطالعات وارد شده را ارزیابی و کیفیت کلی مطالعه را مشخص کردند. سه مقایسه اولیه مشخص شدند، ICBT با حمایت درمانگر در مقابل کنترل لیست انتظار، ICBT با حمایت درمانگر در مقابل ICBT هدایت نشده، و ICBT با حمایت درمانگر در مقابل CBT رو-در-رو. یک مطالعه، CBT هدایت نشده و ICBT با حمایت درمانگر را از نظر بهبود بالینی قابل توجه اضطراب در دوره پس از درمان در بیماران با هم مقایسه کرد که هیچ تفاوتی را در پیامد بین درمانها به دست نیاورد (54 شرکتکننده؛ شواهد با کیفیت بسیار پائین). برای معیارهای نشانه اضطراب عمومی و مختص به یک اختلال و کیفیت زندگی، نمرات پیوسته را با استفاده از تفاوتهای میانگین استاندارد شده (SMD) ارزیابی کردیم. به نظر میرسد ICBT با حمایت درمانگر یک درمان موثر برای مدیریت اضطراب در بزرگسالان باشد. شواهد نشان میدهد که ICBT با حمایت درمانگر میتواند در کاهش اضطراب بیماران تفاوت چشمگیری با CBT رو-در-رو نداشته باشد